Novi lek protiv gojaznosti

Sto sve nece izmisliti farmaceutske kuce, uz pomoc dobro placenih pseudonaucnika, da bi enormno zaradile na ljudskoj nesreci?Kakav protein u mozgu koji izaziva osecaj gladi?Ako je dobro drustvo i dobra klopa ja jedem i kad sam sit!!Ako sam neraspolezen
mogu biti gladan "kao kurjak"
a da mi ne pada napamet da bilo sta pojedem.Srecom mnogo sam cesce dobro raspolozen i u dobrom drustvu!Od mene se te kompanije sigurno nece obogatiti.

Posto je ovaj tekst iz moje struke, da dodam par detalja i uzgred dam nekoliko objasnjenja Leonardu (prvi komentar). Iako nije naznaceno u tekstu, siguran sam da je rec o proteinu koji se zove "leptin". Leonardo, ovaj protein se sintetise u adipoznom tkivu (masno tkivo), a ima receptore u mozgu (hipotalamus, preciznije) i u zavisnosti od njegove interakcije sa tim receptorima regulise se osecaj gladi. Mutacije u genu za leptin dovode do nepravilene regulacije centra za glad u mozgu i do genetske gojaznosti. Mutacija je opisana i kod miseva i kod ljudi. Misevi sa ovom mutacuijom su i do 5 puta tezi od normalnih, a ljudi tj. deca sa mutacijom u genu za letin (Ob gen) vec sa 7 godina mogu da imaju i po 45 kilograma vise od normalne tezine za taj uzrast (mozes onda da zamislis koliko imaju kilograma kada odrastu). Sto se tvoje izjave o farmacutskoj industriji tice, tu se potpuno slazem, ali to je neka druga tema. I za kraj jedan kratak tekst o leptinu koji sam nasao na internetu.

Leptin (from the Greek leptos, meaning thin) is a protein hormone with important effects in regulating body weight, metabolism and reproductive function. The protein is approximately ~16 kDa in mass and encoded by the obese (ob) gene.

Leptin is expressed predominantly by adipocytes, which fits with the idea that body weight is sensed as the total mass of fat in the body. Smaller amounts of leptin are also secreted by cells in the epithelium of the stomach and in the placenta. Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells.

Physiologic Effects of Leptin

Regulation of Food Intake, Energy Expenditure and Body Weight

Leptin in an important component in the long term regulation of body weight. Genetically obese mice with inactivating mutations in the ob gene or the gene encoding the leptin receptor (db gene) have been known for many years and were instrumental in the initial cloning of the ob gene. Recent studies with obese and non-obese humans demonstrated a strong positive correlation of serum leptin concentrations with percentage of body fat, and also that there was a higher concentration of ob mRNA in fat from obese compared to thin subjects. It appears that as adipocytes increase in size due to accumulation of triglyceride, they synthesize more and more leptin. In essence, leptin provides the body with an index of nutritional status.

Leptin's effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure.

Sto sve nece izmisliti farmaceutske kuce, uz pomoc dobro placenih pseudonaucnika, da bi enormno zaradile na ljudskoj nesreci?Kakav protein u mozgu koji izaziva osecaj gladi?Ako je dobro drustvo i dobra klopa ja jedem i kad sam sit!!Ako sam neraspolezen
mogu biti gladan "kao kurjak"
a da mi ne pada napamet da bilo sta pojedem.Srecom mnogo sam cesce dobro raspolozen i u dobrom drustvu!Od mene se te kompanije sigurno nece obogatiti.

Posto je ovaj tekst iz moje struke, da dodam par detalja i uzgred dam nekoliko objasnjenja Leonardu (prvi komentar). Iako nije naznaceno u tekstu, siguran sam da je rec o proteinu koji se zove "leptin". Leonardo, ovaj protein se sintetise u adipoznom tkivu (masno tkivo), a ima receptore u mozgu (hipotalamus, preciznije) i u zavisnosti od njegove interakcije sa tim receptorima regulise se osecaj gladi. Mutacije u genu za leptin dovode do nepravilene regulacije centra za glad u mozgu i do genetske gojaznosti. Mutacija je opisana i kod miseva i kod ljudi. Misevi sa ovom mutacuijom su i do 5 puta tezi od normalnih, a ljudi tj. deca sa mutacijom u genu za letin (Ob gen) vec sa 7 godina mogu da imaju i po 45 kilograma vise od normalne tezine za taj uzrast (mozes onda da zamislis koliko imaju kilograma kada odrastu). Sto se tvoje izjave o farmacutskoj industriji tice, tu se potpuno slazem, ali to je neka druga tema. I za kraj jedan kratak tekst o leptinu koji sam nasao na internetu.

Leptin (from the Greek leptos, meaning thin) is a protein hormone with important effects in regulating body weight, metabolism and reproductive function. The protein is approximately ~16 kDa in mass and encoded by the obese (ob) gene.

Leptin is expressed predominantly by adipocytes, which fits with the idea that body weight is sensed as the total mass of fat in the body. Smaller amounts of leptin are also secreted by cells in the epithelium of the stomach and in the placenta. Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells.

Physiologic Effects of Leptin

Regulation of Food Intake, Energy Expenditure and Body Weight

Leptin in an important component in the long term regulation of body weight. Genetically obese mice with inactivating mutations in the ob gene or the gene encoding the leptin receptor (db gene) have been known for many years and were instrumental in the initial cloning of the ob gene. Recent studies with obese and non-obese humans demonstrated a strong positive correlation of serum leptin concentrations with percentage of body fat, and also that there was a higher concentration of ob mRNA in fat from obese compared to thin subjects. It appears that as adipocytes increase in size due to accumulation of triglyceride, they synthesize more and more leptin. In essence, leptin provides the body with an index of nutritional status.

Leptin's effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure.